Abstract
The effect of CoQ_<10> on myocardial injuries induced by isoproterenol (ISP) s.c. was investigated in rats and dogs. Rats were given ISP (0.1 and 0.5 mg/kg・day), and CoQ_<10> (20 or 40 mg/kg・day) for 28 days. Alteration in electrocardiograms (ECG) patterns for 28 days and the pathologic findings showed endocardial ishemia and necrosis of scattered areas, while no significant changes in plasma LDH, creatine phosphokinase (CPK), GOT and GPT levels were observed. CoQ_<10> decreased the lesions areas induced by 0.1 mg/kg ISP. But unlike those of the rats, the findings in dogs given ISP (0.5 mg/kg・day) for 21 days showed that heart injury did not develop in proportion to the times of ISP given. CoQ_<10> (12, 24 mg/kg・day for 21 days p.o.) improved the heart injuries induced by ISP in dogs, in terms of ECG patterns, plasma LDH, CPK, GOT, GPT levels and the pathologic findings at the last day.
