ビタミン
Online ISSN : 2424-080X
Print ISSN : 0006-386X
ビタミンKの核内受容体を介する新しい作用機構
井上 聡
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ジャーナル フリー

2009 年 83 巻 2 号 p. 59-64

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Vitamin K is a critical nutrient in the bone metabolism. We have demonstrated that SXR, a nuclear receptor steroid and xenobiotic receptor, expressed in bone cells could be activated by vitamin K_2 as a ligand. vitamin K_2 regulates the expression of various bone-related genes in osteoblastic cells. We have identified novel SXR targets that were up-regulated by vitamin K_2 in human osteoblastic cells. Tsukushi, a small leucine-rich repeat proteoglycan, has been shown to contribute to vitamin K-dependent collagen accumulation. Thus, we have discovered an alternative pathway of vitamin K action in the bone via transcriptional regulation utilizing nuclear receptor SXR.

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© 2009 日本ビタミン学会
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