2019 年 62 巻 4 号 p. 205-210
In this review, the microscopic dynamics of lipid membranes analyzed by the dielectric measurement method is reviewed. The dielectric spectra for lipid vesicles involve the information on (i) lateral diffusion of lipid molecules, (ii) its rotational Brownian motion (Lr), (iii) water bound to lipids, and (iv) bulk water. The Lr mode suggested the generation of crevice/pothole on the vesicle membrane by a comparison with other spectroscopic methods. We further used the small sized-proteins to probe the membrane interface. Thereby, it was revealed that the boundary of inter-domain on vesicle membranes plays a role for the crevice/pothole.