2019 年 62 巻 8 号 p. 470-475
For biosensors with host specificity for influenza viruses, we used sugar chains with different coordinations of terminal sialic acid and penultimate galactose. Sialylglycopeptide (SGP) is one of the candidates for detecting molecules in the biosensors for influenza viruses, and we have investigated the host specificity of the viruses using an enzyme-linked immunosorbent assay (ELISA). Using the bovine serum albumin (BSA) localization, we have obtained the stable distribution. The clustering of sugar chains could also enhance and stabilize the binding activity. Comparing with single sugar chains of SGP, clusterized molecules of SGP-BSA showed the reduction of relative errors in the fluctuation in binding activity.