特集「ソフトナノテクノロジーが拓く脳・生体システムの理解と応用」
ヒト幹細胞由来神経細胞を用いた神経回路形成と機能再生
キーワード:
human pluripotent stem cells,
brain organoids,
cell replacement therapy,
disease modeling,
α-synuclein
2024 年 67 巻 9 号 p. 445-449
詳細
2024 年 67 巻 9 号 p. 445-449
Human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells, are emerging as new scientific fields for understanding the pathology of human diseases, regenerative medicine, and drug discovery. In recent years, advanced technologies for cell culture and neuronal differentiation of human cells have provided stable and reproducible methods, contributing to the development of new cross-disciplinary scientific trends alongside various research technologies. Here, we introduce our recent research on brain region-specific neuronal differentiation and brain organoid induction from human pluripotent stem cells, as well as their application for disease modeling and regenerative medicine. Furthermore, we discuss the future direction and application of human pluripotent stem cell technology in advancing scientific discovery.
