Observation of Cancer Treatment Process by Synchrotron Radiation Angiography using X-ray SATICON Camera

- Preclinical Testing of Radiation Therapy and Arterial Embolization -

Abstract

At SPring-8, a microangiography system with spatial resolution down to 10μm (an input field of 9.5 mm × 9.5 mm) was developed using an X-ray direct-conversion type detector incorporating an X-ray SATICON pickup tube for biomedical imaging. Microangiographic experiments were carried out for depicting angiogenic vessels in a rabbit model of cancer. Because of the large depth of field, the microangiography system using a nearly parallel synchrotron radiation beam has advantages over light microscopes for imaging of internal structures of centimeter-sized objects with resolution in the micrometer range. As an application of imaging of tumor blood vessels, preclinical studies using the rabbit model of cancer were conducted for the efficacy evaluation of radiation therapy and the testing of embolic materials in transcatheter arterial embolization on tumor angiogenesis.