YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
一般論文
血管内皮細胞に対するAsp-hemolysinの細胞毒性とサイトカイン遺伝子発現誘導活性
熊谷 健永田 隆之工藤 陽一福地 祐司蝦名 敬一横田 勝司
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2001 年 121 巻 4 号 p. 271-275

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We examined the effects of Asp-hemolysin from Aspergillus fumigatus Fresenius-Muramatsu strain on the viability and cytokine gene expression of human umbilical vein endothelial cells (HUVEC). The cell viability of HUVEC was reduced to 50% by 100 μg/ml of Asp-hemolysin. However, lower concentration of Asp-hemolysin (<30 μg/ml) had no effect on the cell viability. The mRNA expression of such cytokines as tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, IL-8 and granulocyte-macrophage colony stimulating factor (GM-CSF) were also boserved in HUVEC cultured with 30 μg/ml of Asp-hemolysin.

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© 2001 The Pharmaceutical Society of Japan
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