YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
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病院・薬局処方で粉砕される市販錠剤からのラジカルの生成
葛谷 昌之近藤 伸一石川 敬章古田 陽司荒巻 秀樹笹井 泰志山内 行玄
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2005 年 125 巻 4 号 p. 389-396

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  We examined mechanoradical formation in the grinding process of commercial tablets using electron spin resonance (ESR). Mechanoradicals were detected in all tested samples (23 types of commercial tablets) when the ball-milling of tablets was conducted under anaerobic conditions and some were fairly stable even in air. Thus the grinding may cause changes in the physicochemical properties of ingredients included in commercial tablets. Because high quality is demanded in pharmaceuticals, these results suggest more caution should be taken in the grinding of commercial tablets in hospitals and pharmacies.

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© 2005 by the PHARMACEUTICAL SOCIETY OF JAPAN
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