YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
総説
多機能性エンベロープ型人工遺伝子デリバリーシステムの創製
原島 秀吉小暮 健太朗山田 勇磨秋田 英万紙谷 浩之
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2007 年 127 巻 10 号 p. 1655-1672

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  This review introduces a new concept “Programmed Packaging” to develop a non-viral gene delivery system. Based on this concept, multifunctional envelope type nano devices (MEND) were developed for in vitro, in situ and in vivo conditions. A quantitative study to identify a rate limiting step in intracellular trafficking was also shown between viral and non-viral vectors, which indicated an important role of controlled intranuclear disposition for development a safe and efficient non-viral gene delivery system. This review will provide a future direction of non-viral gene delivery system.

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© 2007 by the PHARMACEUTICAL SOCIETY OF JAPAN
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