YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
Regular Articles
Antitumor Activity of the Procyanidins from Pinus koraiensis Bark on Mice Bearing U14 Cervical Cancer
Kun LIQingwang LIJian LITao ZHANGZhengsheng HANDawei GAOFulu ZHENG
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2007 Volume 127 Issue 7 Pages 1145-1151

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Abstract

  Pinus koraiensis Bark Procyanidins Extract (PKBPE) has been used in traditional Chinese medicine for thousands of years. In this study, we determined PKBPE effect on tumor weight, SOD (superoxidate dismutase) activity, the content of MDA (malondialdehyde) through colorimetric analysis antigenic, and expression of Ki-67, p53 and Bcl-2 on mice bearing U14 cervical cancer. Treatment with PKBPE (158 and 250 mg/kg body weight, p.o.) could inhibit U14 cervical carcinoma growth up to 47.68 and 58.94%. In addition, PKBPE enhance the activity of SOD (p<0.01) and decrease MDA content. Furthermore, we also observed that PKBPE treatment significantly inhibited the expression of Ki-67, mutant p53 and Bcl-2 protein (p<0.01). The results suggested that PKBPE showed antitumor activities on U14 cervical carcinoma mice. The mechanism of PKBPE antitumor activity might be associated with free radical production inhibition and regulation of the expression of Ki-67, mutant p53 and Bcl-2 protein.

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© 2007 by the PHARMACEUTICAL SOCIETY OF JAPAN
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