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YAKUGAKU ZASSHI
Vol. 128 (2008) No. 8 P 1203-1207

記事言語:

http://doi.org/10.1248/yakushi.128.1203

一般論文

  Glutathione dose dependently inhibited melanin synthesis in the reaction of tyrosinase and L-DOPA. The inhibition of melanin synthesis was recovered by increasing the concentration of L-DOPA, but not recovered by increasing tyrosinase. Glutathione inhibited the binding between tyrosinase and L-DOPA. Although the synthesized melanin was aggregated within 1 h, the aggregation was inhibited by the addition of glutathione. These results indicate that glutathione inhibits the synthesis and agglutination of melanin by interrupting the function of L-DOPA.

Copyright © 2008 by the PHARMACEUTICAL SOCIETY OF JAPAN

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