YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
一般論文
グルタチオンのメラニン合成阻害機構
松木 光雄渡部 俊彦小笠原 綾子三上 健松本 達二
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128 巻 (2008) 8 号 p. 1203-1207

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  Glutathione dose dependently inhibited melanin synthesis in the reaction of tyrosinase and L-DOPA. The inhibition of melanin synthesis was recovered by increasing the concentration of L-DOPA, but not recovered by increasing tyrosinase. Glutathione inhibited the binding between tyrosinase and L-DOPA. Although the synthesized melanin was aggregated within 1 h, the aggregation was inhibited by the addition of glutathione. These results indicate that glutathione inhibits the synthesis and agglutination of melanin by interrupting the function of L-DOPA.

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© 2008 by the PHARMACEUTICAL SOCIETY OF JAPAN
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