YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Regular Articles
Determination of Density Distribution of Tablets Using Synchrotron X-ray Computed Tomography
Kozo TakayamaSaori OtoguroNobuto OkadaMasato HoshinoNaoto YagiYasuko Obata
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2017 Volume 137 Issue 6 Pages 757-762

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Abstract

 The purpose of this study was to determine the density distribution of scored and round-faced tablets using synchrotron X-ray computed tomography. The tablets were made by direct compression of standard formulations. The density distribution of scored flat-faced tablets was uniform in the whole cross-sectional image. However, the tablet formulated using microcrystalline cellulose (MCC) was very dense at the tip of the score only. It is caused by the poor fluidity of MCC particles. In the case of round-faced tablets, the density in the central section of the tablet was relatively low, compared with those of peripheral areas. These observations correlated well with the results obtained by the finite element method simulation using appropriate material models.

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© 2017 The Pharmaceutical Society of Japan
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