YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
誌上シンポジウム
病変網膜における自発振動活動発生メカニズム
谷口 佳那子小池 千恵子北野 勝則
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ジャーナル フリー

2018 年 138 巻 5 号 p. 685-692

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抄録

 Rhythmic neural activities are observed in many brain regions, and these are considered to play an important role in neural information processing. On the other hand, distinct rhythmic neural activities emerge under several pathological conditions, suggesting that rhythmic neural activity has a close relation to brain function and dysfunction. In many pathological cases, the intrinsic property of unusual rhythm generation in a neuron or a neuronal network is prevented under normal conditions, but released by the pathological condition. Therefore, it may be useful to explore which conditions determine rhythm generation in order to understand the mechanisms of brain function/dysfunction. The pathological retina in retinal degeneration exhibits rhythmic neural activity not observed in the healthy retina. In this review, we first provide a brief introduction to the possible mechanisms of rhythm generation in a neural system. Then we introduce experimental evidence of rhythm generation in the pathological retina, as well as two hypotheses regarding this mechanism. Finally, we raise several issues to be solved for the further understanding of pathological rhythm generation.

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© 2018 The Pharmaceutical Society of Japan
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