Studies on the Derivatives of Aminoalcohols. V. Anti-inflammatory Activities of N-(3-Dialkylamino-2-hydroxypropyl)-4-phenylpiperidine·Dihydrochloride

Abstract

In order to develope a non-steroidal anti-inflammatory drug, N-(3-dialkylamino-2-hydroxypropyl)-4-phenylpiperidine·2HCl was synthesized. Five compounds were examined for anti-inflammatory effects on swelling of rat hind paw induced by dextran and on mice scald oedema, diuresis effects, depression effects of normal body temperature. In general, the order of anti-inflammatory effects of these compounds was IIIe>IIId>IIIb>IIIc>IIIa. The inhibition percentage of scald oedema of compound No. IIId, e were higher than that of cortisone acetate and aspirin. These compounds had scarcely diuresis action. The order of depression effects on normal body temperature was IIIc>aminopyrine>IIIe≒IIId>IIIb>IIIa.