固形剤の物性に関する製剤学的研究(第5報)各種粉体の圧縮圧とその成形物の強度について

抄録

The relationship between the strength of compressed powder compacts and compaction pressure was investigated in several kinds of powders. Boring hardness measurements were carried out on the compacts prepared by static compression. The reciprocal of boring speed 1/v and the constant k in eq. (1) were used as measures of compact strength. Crushing strength for tablets made by a rotary tablet machine was also measured. The strength of each compact reached a limited value under high compaction pressure, which was considered to be the characteristic value for each powder. Compact strength decreased with the addition of a lubricant. Because the additivity of tablet strength could be observed, tablet strength in binary powder systems could be estimated from the strength of each component and from the mixing ratio.