Effects of Dai-Saiko-Toh, Sho-Saiko-Toh and Saiko-Keishi-Toh on body weight and weights of various organs of rats were observed, and histological changes in various organs were examined. While no difference in the rate of body weight increase was noted among normal rats and those treated with Dai-Saiko-Toh or Saiko-Keishi-Toh, Sho-Saiko-Toh treated rats gained weight faster than normal. A weight increase of the adrenal glands and atrophy of the thymus were observed in rats treated with Dai-Saiko-Toh or Sho-Saiko-Toh. Histologically, the adrenal cortex showed lipid accumulation in the lower zona fasciculata in Dai-Saiko-Toh and Sho-Saiko-Toh treated rats. In the liver, no change in weight or histology was noted in any group.
