In order to obtain more hydrophylic and more potent hemostatics, 2-semicarbazono-1, 2-naphthoquinone analogs with or without sulfonic acid or its salts at 4, 5, 6, 7 or 8 position (III and IV) and 4-semicarbazido-1, 2-naphthoquinone analogs (V) were prepared and their hemostatic activities and acute toxicities were examined. Among these compounds, more hydrophilic 2-semicarbazono-1, 2-naphthoquinone analogs with sulfonic acid group (IIIj and IIIr) as well as less hydrophilic 2-semicarbazono-1, 2-naphthoquinones without sulfonic acid group (IVa and IVh) and 4-semicarbazido-1, 2-naphthoquinone analogs (Ve) showed the activity comparable to that of 2-semicarbazono-1, 2-naphthoquinone (II) or carbazochrome sodium sulfonate (I) in shortening the bleeding time.
