スルホニル尿素誘導体とアンモニア間の分子付加物形成とその微粉化への応用
1981 年 101 巻 1 号 p. 55-63
詳細
1981 年 101 巻 1 号 p. 55-63
Ammonia adduct formation was confirmed in 5 sulfonylureas including acetohexamide, glyclopyramide, chlorpropamide, tolazamide, and tolbutamide. The thermal and physico-chemical properties of these adducts and the recovered chemicals were investigated by differential scanning calorimetry, thermogravimetry, thermomicroscopy, X-ray powder diffractometry, and scanning electron microscopy. From the specific surface area measurement by a gas adsorption (BET) method, it was found that effective particle size reduction was achieved with sulfonylureas recovered by desorbing NH3 from the adducts. Further, the effect of particle size on the temperature range of melting and the heat of fusion was investigated with glyclopyramide, tolazamide, and tolbutamide. It was found that, in spite of the same purity, the melting peaks of size-reduced particles via these NH3 adducts became sharper but shifted to lower temperature and the heats of fusion were smaller than those of the original sulfonylureas.
