YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
生薬の生物活性成分に関する研究 Streptozotocinによる病態モデルを用いた山茱萸抗糖尿病活性成分の検討
山原 條二壬生 寛之沢田 徳之助藤村 一滝野 晋吾吉川 雅之北川 勲
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1981 年 101 巻 1 号 p. 86-90

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Antidiabetic activity of Chinese prescription "Hachimi-Gan"was studied by using diabetic rats induced by streptozotocin. Changes in water consumption, urine volume, blood and urinary glucose were studied in order to examine the activity. "Hachimi-Gan"exhibited the antidiabetic activity, while the boiling water extract of "Hachimi-Gan"was ineffective. Among the components of crude drugs of "Hachimi-Gan, "the ether extract of Corni Fructus (The seed of Cornus officinalis) was found to be potent for these diabetes rats. Fractionation of the ether extract revealed that ursolic acid showed the antidiabetic activity and oleanolic acid decreased the amount of water consumption and urine volume.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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