YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
五味子の薬理学的研究(第1報)Gomisin AおよびSchizandrinの一般薬理作用
前田 信也須藤 和彦油田 正樹池谷 幸信田口 平八郎吉岡 一郎原田 正敏
著者情報
ジャーナル フリー

1981 年 101 巻 11 号 p. 1030-1041

詳細
抄録

General pharmacological studies were made on gomisin A and schizandrin which are the constituents of "Hoku-gomisi", the fruit of Schizandra chinensis BAILL. (Schizandraceae) used as an antitussive and a tonic. In the experiments by using mice, gomisin A prolonged intensively hexobarbital-induced sleeping time at doses smaller that 1/40 of LD50, inhibited spontaneous and methamphetamine-induced motor activity, and showed a hypothermic effect and at higher doses an analgesic effect by pressure pain method, while schizandrin showed the same effects except for the sleep-prolongating effect and inhibited writhing symptom by AcOH. At higher doses, both compounds showed a muscle relaxant effect. From these results, it was conceivable that the action of both compounds was a sedating or tranquilising effect. The efficacy of gomisin A was durable and intense, and that of schizandrin was transient. But on the analgesic effect gomisin A was inferior to schizandrin. Moreover, gomisin A showed an antitussive effect in guinea pigs. In the experiments by using rats, gomisin A showed inhibitory effects on gastric contraction (i.v.) and stress-induced gastric ulceration (p.o.), whereas schizandrin showed the same actions, choleretic action, and an inhibitory effect on gastric secretion. In the inhibition of gastric ulceration, the action of schizandrin was superior to gomisin A, and it was suggested that the action of gomisin A depended on the inhibition of gastric contraction to depress stressor factor, and that the action of schizandrin was mainly due to the inhibition of gastric juice secretion and gastric contraction.

著者関連情報
© by the PHARMACEUTICAL SOCIETY OF JAPAN
前の記事 次の記事
feedback
Top