ピリミジン誘導体の合成と医薬品への開発研究

抄録

Works on the synthesis of pyrimidine derivatives and thier structure-activity relationships for the development of analgetic-antipyretic, antiinflammatory, sedative and diuretic drugs are described. This article is constructed as follows : 1) 1, 3-disubstituted 5-dialkylaminouracils and aminopyrine 2) 1, 5-disubstituted or 1, 3, 5-trisubstituted barbituric acids and phenylbutazone 3) 5, 6-dialkyluracils and barbital 4) 2, 4-dioxo-1, 2, 3, 4-tetrahydropyrrolo [2, 3-d]-or [3, 2-d] pyrimidines and caffeine. As a result, bucolome (5-butyl-1-cyclohexylbarbituric acid) is developed as a antiinflammatory drug.