YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Tenuazonic Acid関連化合物の研究(第4報)3-Acetyltetramanilideと置換ベンツアルデヒド縮合物の合成とその抗腫瘍性
山口 達明吉田 精輔樋口 貞夫坂本 曜子斉藤 仁俊由岐 英剛
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1981 年 101 巻 2 号 p. 125-131

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Condensation products of 3-acetyltetramanilide (3-(1'-anilinoethylidene) pyrroline-2, 4-dione) with 13 kinds of substituted benzaldehydes were prepared. The compounds synthesized were tested for the antitumor activities against Yoshida sarcoma cells in vitro and Ehrlich ascites carcinoma in vivo. 3-Acetyl-5-benzylidenetetramanilide was shown to be effective both in vivo and in vitro. The relative reactivities of condensation reactions of 3-acetyltetramanilide, 3-acetyltetronanilide and 3-acetylthiotetronanilide with benzaldehyde under a variety of catalysts were examined.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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