1981 年 101 巻 2 号 p. 125-131
Condensation products of 3-acetyltetramanilide (3-(1'-anilinoethylidene) pyrroline-2, 4-dione) with 13 kinds of substituted benzaldehydes were prepared. The compounds synthesized were tested for the antitumor activities against Yoshida sarcoma cells in vitro and Ehrlich ascites carcinoma in vivo. 3-Acetyl-5-benzylidenetetramanilide was shown to be effective both in vivo and in vitro. The relative reactivities of condensation reactions of 3-acetyltetramanilide, 3-acetyltetronanilide and 3-acetylthiotetronanilide with benzaldehyde under a variety of catalysts were examined.