YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
心筋障害と血中酸素分圧との関連におけるSympathomimetic Aminesの作用
沢辺 隆司府川 和永佐藤 進
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ジャーナル フリー

1981 年 101 巻 2 号 p. 161-168

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We measured the blood oxygen tension (Po2) in the rat aorta in connection with cardiac lesions caused by the subcutaneous administration of sympathomimetic amines. The degree of cardiac lesions caused by l-isoproterenol, which acts predominantly on the β-receptor, or dl-norepinephrine, which acts predominantly on the α-receptor, was dose dependent, and these drugs decreased the Po2 in the same dose range. The decrease in Po2 due to dl-norfenefrine, which causes very little cardiac lesion and acts on the α-receptor, was not significant. Moreover, it is ascertained that cardiac lesions and a decrease in Po2 caused by l-isoproterenol could be prevented by pretreatment with propranolol and that cardiac lesions and a decrease in Po2 caused by dl-norepinephrine could be prevented by pretreatment with phentolamine.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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