YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
血中および尿中のピンドロールの高速液体クロマトグラフィーによる定量
高岸 靖小倉 敏弘富田 敬三大久保 洋子坂元 照男
著者情報
ジャーナル フリー

1981 年 101 巻 2 号 p. 190-193

詳細
抄録

A high pressure liquid chromatography (HPLC) by use of ultraviolet absorption detector was examined for the determination of pindolol in the plasma and urine. The pindolol extracted from biological fluid and the disopyramide used as an internal standard, were chromatographed as ion pairs with heptanesulphonic acid by use of Nucleosil 7C18 reverse phase column. The coefficients of variation for the peak height ratio were 2.7% (50 ng/ml) to 4.3% (10 ng/ml) in the plasma and 2.3% (20 μg/ml) to 3.8% (5 μg/ml) in the urine. The detection limits of pindolol were about 2 ng/ml in the plasma and 0.5 μg/ml in the urine. The plasma levels and the urinary excretion rates of pindolol after oral administration of 10 mg pindolol to a healthy male volunteer could be measured by this method. This method is more sensitive and reproducible than the fluorometric method and may be used for a clinical pharmacokinetic study and a bioavailability study of pindolol.

著者関連情報
© by the PHARMACEUTICAL SOCIETY OF JAPAN
前の記事 次の記事
feedback
Top