1981 年 101 巻 2 号 p. 97-117
Snake post-synaptic neurotoxins can be classified into the following types : (i) shortchain neurotoxins ; the neuromuscular block is easily reversible. (ii) long-chain neurotoxins ; the neuromuscular block is almost irreversible. Judging from these results, shortchain neurotoxin is more useful for the isolation of acetylcholine receptor from the electric organ of fishes, muscles and thymus. Long-chain neurotoxin seem to be a useful tool to detect anti-acetylcholine receptor antibodies in the sera of patients with myasthenia gravis. Snake neurotoxins serve to clarify the function of neurotransmitters at the cholinergic receptor site in the level of molecular biology, and these results may be helpful in the elucidation of the pathogenesis of myasthenia gravis.