YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
鎮痙剤の研究(第7報)N-Alkyl Diarylmethylenequinolizidinium Bromides, N-Alkyl Diarylmethyleneindolizidinium Bromidesおよび関連化合物の構造活性相関
越中 栄一久保 信治松原 一誠森川 宏二加藤 日出男
著者情報
ジャーナル フリー

1981 年 101 巻 3 号 p. 259-265

詳細
抄録

As a part of studies on antispasmodics, the structure-activity relationship was examined in N-alkyl diarylmethylenequinolizidinium bromides and N-alkyl diarylmethyleneindolizidinium bromides (6-33), which can be classified in to γ-substituted piperidine, β-substituted piperidine and β-substituted pyrrolidine. Compounds (6-33) exhibited potent anticholinergic activity due to having conformationally rigid bicyclic hetero rings compared to monocyclic antispasmodics such as diphemanil methylsulfate (1), timepidium bromide (2), prifinium bromide (4) and their unmodified compounds (3 and 5). Several compounds among them exhibited potent anticholinergic activity greater than that of atropine.

著者関連情報
© by the PHARMACEUTICAL SOCIETY OF JAPAN
前の記事 次の記事
feedback
Top