ステロイドの臨床分析(第16報)プレグナンジオール硫酸抱合体の合成
1981 年 101 巻 3 号 p. 282-285
詳細
1981 年 101 巻 3 号 p. 282-285
Three possible sulfates of pregnanediol (1) were prepared by the following procedure. Partial acetylation of 1 with acetic anhydride in pyridine gave chromatographic separable monoacetates, 3α-acetoxy-5β-pregnan-20α-ol (3) and 20α-acetoxy-5β-pregnan-3α-ol (4), in appropriate amount. Sulfation with pyridine-SO3 complex of 3 and 4, followed by saponification gave desirable pregnanediol monosulfates, 20α-sulfooxy-5β-pregnan-3α-ol (6) and 3α-sulfooxy-5β-pregnan-20α-ol (8), respectively. Pregnanediol 3, 20-disulfate (9) was obtained from 1 with excess reagent.
