アミノ安息香酸エチルのセルロース膜透過におよぼすマクロゴール400の影響

抄録

To clarify the diffusional behaviors of benzocaine in the presence of macrogol 400 (PEG), viscosity, solubility and cellulose membrane permeation rate of benzocaine were determined with PEG solutions of various concentrations. With an increase in PEG concentration, permeation rates of benzocaine from solutions (benzocaine conc. <solubility) decreased due to an increase in viscosity of the solution. From suspensions (benzocaine conc. >solubility), however, permeation rates increased due to an increase in benzocaine solubility.