ラットにおけるループ利尿剤, フロセミドおよびピレタニドの投与量依存性

抄録

Administrations of loop diuretic agents, furosemide and piretanide from the femoral vein and portal vein infusion of several doses to rats were carried out, and then, plasma concentrations and cumulative amounts excreted in the urine and bile of the drug were determined. The relationship between doses and the area under the plasma concentration-time curves (AUC) after intravenous administrations was nonlinear over the dose range from 10 to 30 mg/kg. Active renal excretion process was also supported, and then, it was observed that AUC's after intraportal infusion of each drug varied in accordance with alteration of infusion time in a dose of 10 mg/kg.