直腸の組織透過性におよぼす薬物の影響(第1報)スルファグアニジンの直腸透過性におよぼす製剤添加物の影響

抄録

The effect of additives such as sodium deoxycholate, sodium lauryl sulfate, disodium ethylenediaminetetraacetate, polyethylene glycol 400, polysorbate 80, on the rectal permeability was compared by measuring the rectal absorption of sulfaguanidine from the perfused solution and the apparent rectal clearance of i.v. injected sulfaguanidine in the rat. The absorption and apparent rectal clearance of sulfaguanidine in the rat rectum were increased by the addition of these additives, except for lower concentration of polyethylene glycol 400. There was a very favorable correlation between the increasing ratio of apparent absorption rate and ratio of apparent rectal clearance of sulfaguanidine. In addition the simultaneous change in permeability in both directions (rectum to blood, blood to rectum) was clarified. The cause was found to be due to a histological change in the tissue of the rectum, and it was also found that these changes were different according to the natures of the additives.