YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
ボルタンメドリー検出器付高速液体クロマトグラフィーによるグルタチオン, D-ペニシラミン, の定量
井上 健次大竹 盾夫野田 克己京極 和旭内田 詔爾
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1982 年 102 巻 7 号 p. 659-665

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A method for the simultaneous determination of glutathione and D-penicillamine in the human blood was developed by use of a high-performance liquid chromatography with a voltammetric detector. The glutathione and D-penicillamine values in the blood of patients with rheumatoid arthritis treated with D-penicillamine (100-300 mg/d) were studied. It was found that the glutathione values in the blood of responders to D-penicillamine (10 patients) were 25% higher than that of non-responders (10 patients) (p<0.01), and that D-penicillamine values in the blood were little in both groups. The measurement of glutathione could be used both as a parameter of disease activity and as a tool for distinguishing responders from non-responders to D-penicillamine.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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