YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
鎮痙薬の研究(第4報)N-(2-Acyloxyethyl)-N-(1,3-dioxolan-2-and 4-ylmethyl)-N, N-dimethylammonium誘導体の合成と抗アセチルコリン作用
菅井 三郎長谷川 賀洋梶原 良夫内藤 泰男吉田 誠一郎赤星 三彌
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1983 年 103 巻 10 号 p. 1034-1041

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N-(2-Acyloxyethyl)-N, N-dimethyl-N-(1, 3-dioxolan-2-and 4-ylmethyl) ammonium compounds were synthesized and tested for anticholinergic activity. It was found that among these compounds the N-(2-acyloxyethyl)-N-(1, 3-dioxolan-2-ylmethyl) ammonium derivatives exhibited more potent activities than the N-(2-acyloxyethyl)-N-(1, 3-dioxolan-4-ylmethyl) ammonium and N-(3-acyloxypropyl)-N-(1, 3-dioxolan-4-ylmethyl) ammonium ones.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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