1983 年 103 巻 10 号 p. 1068-1076
Pharmacokinetic parameters estimated using a program SIMPLEX based on a direct search method with a microcomputer were compared with those using the well-established nonlinear regression program NONLIN based on the Hartley's modification of the Gauss-Newton method with a large computer. Comparison of parameters calculated using these programs gave excellent agreement. Average computational time for the SIMPLEX was 7.1 min for 12 sets of data analyzed in this study and the computational time was reduced by 50% with a basic compiler. Parameters of the SIMPLEX in this study were compared to those of simplex method incorporated into MULTI program by Yamaoka et al. for microcomputer. Further, it was found that the combined use of SIMPLEX and NONLIN compensates several disadvantages of NONLIN. From the above results, it was concluded that SIMPLEX performed with a microcomputer can be replaced by NONLIN.