YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Pyridinol誘導体の研究(第3報)2H-Pyrido[3,2-b]-1,4-oxazin-3-one誘導体の合成と薬理作用についてその2
武田 秀雄久道 周彦
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1983 年 103 巻 2 号 p. 153-164

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Twenty five kinds of derivatives of 4-(3-dialkylamino-2-hydroxypropyl)-2H-pyrido-[3, 2-b]-1, 4-oxazin-3-one (9a-13e) were synthesized by three different methods, and obtained as hydrochloride. The following results were obtained from the preliminary investigation on the local anesthetic and the analgesic activities (mouse writhing test) of these synthesized compounds. Almost all of the compounds were inferior to cocaine or lidocaine on the local anesthetic action ; these were approximately equivalent to or slightly weaker than pyrabital.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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