YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
ヒト尿中に存在する非力リクレイン性アルギニンエステラーゼについて
松田 兆史秋浜 澄行藤本 幸男守屋 寛宮下 厚
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1983 年 103 巻 2 号 p. 198-202

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A new arginine ester hydrolyzing enzyme in the human urine (human urinary arginine esterase, HUAE) was found. The content levels of this new enzyme, determined by N-α-tosyl-L-arginine methyl ester (Tos-Arg-Me) hydrolyzing activity, were measured to be 0.34 to 0.86 nmol/min/ml of human urine and the percentage of content level of this enzyme was calculated to be about 10 to 20 per cent of the total Tos-Arg-Me hydrolyzing activity. HUAE was partially purified and then separated into two forms (HUAE-1 and -2) by DEAE-cellulose chromatography. The approximate molecular weights of HUAE-1 and -2 were estimated to be 4.8×104 and 3.0×104 by Sephadex G-100 gel filtration, respectively.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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