YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
シリカゲルを担体とする水性二相液体クロマトグラフィーシステムにおける薬物およびその代謝物の保持挙動
原 昭二井實 孝則松本 武司
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1983 年 103 巻 2 号 p. 240-244

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The retention indices of 17 drugs and metabolites including hypnotics, antiepileptics, analgesics, and central nervous system stimulants in liquid-liquid chromatography were systematically examined to devise a highly efficient extraction and fractionation procedure in biological fluid analysis. A high performance system incorporating an acid-treated silica gel column and a UV-detector was assembled to determine the capacity ratios in aqueous two phase organic solvents consisting of diethyl ether and n-hexane (1 : 0, 7 : 3, 1 : 1, 3 : 7 v/v). The corrected capacity ratios (k'cor) of the drugs in an aqueous organic phase system were calculated from the experimental retention data and phase ratios in liquid-liquid chromatography. A linear correlation between the logarithm of the k'cor value and the logarithm of solvent composition in a liquid-liquid partition system was demonstrated in this study.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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