Effect of 3-(di-2-thienylmethylene)-5-methyl-trans-quinolizidinium bromide (HSR-902), a new antispasmodic agent, on the microcirculation of gastric mucosa in rabbits treated with neostigmine bromide was investigated. Intravenously administrated HSR-902 (25μg/kg) increased the blood flow of gastric mucosa in rabbits treated with neostigmine bromide (50μg/kg, i.v.). The increased microcirculation was recognized in five of eight rabbits after HSR-902 (25μg/kg, i.v.) administration. HSR-902 administered at a dose of 50μg/kg (i.v.) completely restored the decreased blood flow to the control level without exerting significant effects on systemic blood pressure, and inhibited the elevated stomach movement evoked by neostigmine bromide. This effect was durable in almost all rabbits. On the other hand, intravenous administrations of 50μg/kg of butylscopolamine bromide, timepidium bromide and cyclonium iodide failed to restore the decreased microcirculation induced by neostigmine bromide. These results suggest that HSR-902 may be effective in repairing ischemia and oligemia of gastric ulcer which result from decreased microcirculation in the stomach mucosa.
