柴胡剤の薬理学的研究(第3報)柴胡剤のラットにおける実験的炎症に対する作用

抄録

Actions of three "saiko-zai, " daisaiko-to, shosaiko-to and saikokeishi-to consist of basic (BASE) and additional (A, B and C, respectively) prescriptions, on the experimental models of inflammation in rats was studied. BASE did not produce any inhibitions on paw edema induced by carrageenin, dextran and burn, but had a potent action on adjuvant arthritis. A and BASE+A (daisaiko-to) inhibited paw edema induced by carrageenin and dextran as much as aspirin did, and also inhibited adjuvant arthritis, in which secondary stage of inflammation was suppressed more strongly than primary stage. C and BASE+C (saikokeishi-to) inhibited dextran-induced paw edema to the same extent as aminopyrine, and BASE+C showed a potent anti-inflammation on adjuvant arthritis. On the other hand, any inhibitory actions on various inflammatory models by B and BASE+B (shosaiko-to) were not observed. None of BASE and additional prescriptions showed a protective action on heat-induced hemolysis of rat erythrocytes. These results suggest that daisaiko-to and saikokeishi-to possess potent inhibitory actions on acute and chronic inflammation in rats.