Twenty kinds of derivatives of 4-(2-dialkylaminoethyl)-3, 4-dihydro-2H-pyrido[3, 2-b]-1, 4-oxazine (13a-17d) were synthesized by two different methods, and obtained as hydrochloride. The following results were obtained by the use of the preliminary investigation on the local anesthetic and the analgesic activities (mouse writhing test) of these synthesized compounds. It was proved that the duration time of the local anesthetic action of almost all these compounds was inferior to that of cocaine or lidocaine, but, in quite few cases, superior to that of cocaine or lidocaine ; the analgesic action of these compounds was approximately equivalent to or slightly weaker than that of pyrabital.
