1984 年 104 巻 11 号 p. 1109-1121
In many mammalian cells, cyclic adenosine 3', 5'-monophosphate (cAMP) and calcium (Ca2+) served interrelated second messenger functions in the control of cellular function and growth. We have investigated; (i) the effects of cAMP and Ca2+ on the control of histamine release from mast cells stimulated by active oligomers, of which releases are dependent on extracellular Ca2+ or not. (ii) the fluctuations of cAMP levels, PGE1-binding, and several cellular functions because of the cells respond to Bt2cAMP, and PGE1 with decreased growth rate and increased expression of more mature, differentiated mast cell phenotypes, and also because PGE1 specifically binds to the cells and elevates cAMP levels. (iii) the cell cycle-dependent changes of cAMP and Ca2+ levels, and certain cellular functions in synchronous mastocytoma P-815 cells.