YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
散剤の吸湿とその防止に関する研究 : 散剤の吸湿に及ぼす自動分包機の熱板温度の影響
高山 明越川 富雄奥村 勝彦堀 了平上能 伊公雄北澤 式文
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1984 年 104 巻 11 号 p. 1174-1180

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The effect of heating plate temperature for automatic sealing of wrapping paper on moisture protection of powder preparations was investigated. Powder preparations used were pulverized sodium valproate tablet, lactose monohydrate, potato starch, D-glucose, sodium chloride, fructose and potassium iodide, and these had different critical relative humidities. Five wrapping papers having various moisture permeabilities were also used. It was revealed that (1) heating plate temperature played an important role for moisture protection of pharmaceuticals ; (2) moisture permeation may be derived through sealed area due to incomplete sealing at low temperatures (<100°C) and also through sealed edge due to melting of laminated polyethylene at high temperatures (150°C<); (3) suitable selection of the temperature is necessary to minimize moisture permeation and to protect powder preparation from hygroscopicity.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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