YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
医薬品の分解とその安定化(第20報)ジピリダモールの光分解反応とその安定化
気賀沢 和雄清水 弘明林田 滋大久保 一三
著者情報
ジャーナル フリー

1984 年 104 巻 11 号 p. 1191-1197

詳細
抄録

Photodecomposition of dipyridamol (I) on thin layer chromatography (TLC) and in org. solvents was studied. It was found that photodecomposition product (II) was yielded by oxidation of piperidine ring moiety of I, and the photolysis of I in org. solvents were pseudo first order kinetics. These reactions were shown to be inhibited by the addition of pyrazolone derivatives that gave the charge transfer complex of I, which had a stabilizing effect in org. solvents. It was comfirmed that the charge transfer complex between I and pyrazolone derivatives were composed of 1 : 1 molar ratio. Further, the stability of tablets of I was studied by aging in a room (at room temp., in room light). No significant decrease of I contents after aging for five years in a room was observed, and neither high performance liquid chromatography nor TLC chromatograms showed decomposition products.

著者関連情報
© by the PHARMACEUTICAL SOCIETY OF JAPAN
前の記事 次の記事
feedback
Top