抄録
Radiosensitizing effect of pepleomycin (PEP), an antitumor drug derived from bleomycin, was examined in mouse. PEP was intraperitoneally injected into ICR male mice. Mice irradiated with 70kVp of soft X-ray were observed for 30d. By comparing the mice survival time of the control group with that of PEP-treated group, radiosensitizing effect of PEP was detected as a shortening of the survival time. The enhancement ratio (ER) calculated by mice survival time was 1.29. PEP was most effective when injected 1 h before the irradiation, and the effect was dose dependently inhibited by a radioprotector, cysteamine (MEA).
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