YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Nafamstat Mesilateの水溶液中での安定性に関する研究(第1報)各種pH及び温度条件下における反応の動力学的検討
荒川 勝雅畔取 政行杉山 哲資来海 正輝青山 卓夫
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1985 年 105 巻 5 号 p. 512-516

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Kinetics of nafamstat mesilate in aqueous solution was studied and the following findings were obtained. In aqueous solution, nafamstat mesilate was exclusively hydrolyzed to form its moieties of 4-guanidinobenzoic acid and 6-amidino-2-naphthol. The hydrolysis followed a pseudo-first order reaction and was catalyzed by each hydrogen ion, hydroxyl ion and water depending on the pH conditions in the pH range of 1-7, the following the kinetic law of k0=kHαH+kH2O+kOHαOH. In the pH range of 3-9, the buffer concentration effect was observed. The ionic strength effect at pH 1 and 9 among pH 1, 3 and 9 studies was also observed. Nafamstat mesilate was most stable under acidic conditions, i.e. at pH 3.29 and 3.21 at 50°C and 60°C, respectively, as shown by pH-rate profile.

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