1985 年 105 巻 6 号 p. 531-541
Kyotorphin (Try-Arg) is a neuropeptide originally isolated from bovine brains. We have demonstrated that kyotorphin-induced opioid analgesia may be caused via a release of enkephalin from the brain. Kyotorphin was found unevenly in the rat brain and concentrated in the synaptosomal fraction. Furthermore we demonstrated that kyotorphm is synthesized in the synaptosomal fraction, suggesting that kyotorphin might play a neurotransmitter/neuromodulator role in the brain.