YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
鎮痛活性ペプチド・キョートルフィンの脳からの単離とその鎮痛作用機序に関する研究
塩見 浩人植田 弘師
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1985 年 105 巻 6 号 p. 531-541

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Kyotorphin (Try-Arg) is a neuropeptide originally isolated from bovine brains. We have demonstrated that kyotorphin-induced opioid analgesia may be caused via a release of enkephalin from the brain. Kyotorphin was found unevenly in the rat brain and concentrated in the synaptosomal fraction. Furthermore we demonstrated that kyotorphm is synthesized in the synaptosomal fraction, suggesting that kyotorphin might play a neurotransmitter/neuromodulator role in the brain.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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