1985 年 105 巻 6 号 p. 562-568
Anti-sialidase activity was studied in a part of a research on pharmacological actions of medicinal plants. Kakkon-to ( ?? ?? ?? ) (extracted granular 2.5 g/20 ml H2O) showed sialidase inhibition activity (64.4%). Taiso ( ?? ?? ), Mao ( ?? ?? ), Keihi ( ?? ?? ) and Shakuyaku ( ?? ?? ) which were constituents of Kakkon-to inhibited sialidase activity and Mao showed the strongest inhibition effects. The medicinal plants extracts showing the inhibition of sialidase contain various tannins. The anti-sialidase activity of tannic acid varied according to the concentration of tannic acid and galloylglucoses (1, 2, 6-tri-, 1, 2, 3, 6-tetra- and 1, 2, 3, 4, 6-pentagalloyl-β-D-glucose) found in Gobaishi ( ?? ?? ?? ) and Boshokushi ( ?? ?? ?? ) etc. Those extracts showed very strong inhibition, depending on the number of galloyl group but without relation with gallic acid and glucose. Effects of galloylglucoses on Vero cells were examined. Vero cells were impaired at the concentration of 10μg/ml. Anti-sialidase activity of flavones was examined and among flavones, kaempferol showed the strongest inhibition effects.