YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
α-及びβ-シクロデキストリン結晶化度の粉砕による変化
仲井 由宣山本 恵司寺田 勝英梶山 篤司
著者情報
ジャーナル フリー

1985 年 105 巻 6 号 p. 580-585

詳細
抄録

The crystallinity of cyclodextrins has been evaluated by using powder X-ray diffraction techniques. α-Cyclodextrin·6H2O and β-cyclodextrin·12H2O were transformed into dehydrate forms by heating at 110°C for 3 h in vacuo. When the cyclodextrin hydrate or dehydrate was ground by vibrational mill, it converted from crystalline state to amorphous state. Crystallinities of intact and ground cyclodextrins were calculated by Ruland's method. In Ruland's method, as the integral upper limit affects significantly the evaluation of crystallinity, we determined the crystallinity by using continuous regions of the integral upper limit. The crystallinities and disorder parameters were determined as 83.4%, 3.2A2, for α-cyclodextrin·6H2O, 87.6%, 4.3A2, for β-cyclodextrin·12H2O and 51.5%, 4.3A2 for β-cyclodextrin dehydrate, respectively. The crystallinities of these three crystals decreased to about 8% by 3 min grinding.

著者関連情報
© by the PHARMACEUTICAL SOCIETY OF JAPAN
前の記事 次の記事
feedback
Top