YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
腸溶性ニフェジピン固体分散体の溶解機構について
長谷川 明彦川村 理恵中川 寛杉本 功
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1985 年 105 巻 6 号 p. 586-592

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Recrystallization behavior of nifedipine from the supersaturated solution containing various polymers was mainly investigated to clarify the mechanism of the supersaturation phenomena from the solid dispersions of nifedipine with enteric coating agents in JP X 2nd fluid (pH 6.8). The recrystallization of nifedipine was remarkably inhibited in the medium containing non-ionic water soluble cellulose polymers or anionic cellulose polymers (enteric coating agents). However, the inhibitory effect on the recrystallization of nifedipine was little using the other type of polymer, such as polyvinylpyrrolidone or methacrylic acidmethacrylic acid methyl ester copolymer. Microscopic observations of the shape of recrystallized nifedipine suggested that a physico chemical interaction between polymer and nifedipine, such as an adsorption of polymers on the surface of nifedipine nuclei, was a main factor affecting the crystal growth of nifedipine.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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