YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Oxindoles(第5報)オキシインドール-スピロ二量体の選択的ソルボリシス
近藤 嘉和三田寺 洋二野副 重男
著者情報
ジャーナル フリー

1985 年 105 巻 8 号 p. 724-729

詳細
抄録

Isatin reacts in the presence of pyridine with acetic anhydride to give spiro-dimers, 1 and 2. The former was converted with acid to 2. Treatment of 2 with diazomethane yielded methylester (3) which was converted with the excess reagent to cyclopropane derivative 4. Compound 1 was heated under reflux in methanol to yield 5, 6-dihydrobenz [c, d] indolinone (5) (46.6%) together with a little 6, 7, and 8. On treatment with anilines or hydrazine, 1 was converted to anilides or 2, 3-dihydro-4, 4-phthalazinone derivative.

著者関連情報
© by the PHARMACEUTICAL SOCIETY OF JAPAN
前の記事 次の記事
feedback
Top