YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
強心性植物成分の研究 : キサンチン誘導体の構造変換と生理活性について
榊原 仁作植田 泰誠大崎 勉竹谷 和視安藤 佐和子
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1985 年 105 巻 8 号 p. 730-735

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In order to examine the relationship between the biological activities and structural variations of xanthine derivatives, several 1-aminoxanthines were synthesized from 1-methylxanthines and their cardiac activities were examined. Xanthine derivatives, such as caffeine, theobromine, 7-ethyltheophylline, 7-allyltheophylline, proxyphylline, and diprophylline were allowed to react with hydrazine hydrate to give 1-aminoxanthines and the following biological testings were carried out : (a) phosphodiesterase inhibition (b) activities on guinea-pig papillary muscle (c) activities on guinea-pig atrium (d) activities on guineapig tracheal muscle. The cardiac activities of 1-aminoxanthines were weaker than those of theophylline.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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